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Hippo Kinases MST1/2 Regulate Immune Cell Functions in Cancer, Infection, and Autoimmune Diseases
Critical Reviews in Eukaryotic Gene Expression ( IF 1.6 ) Pub Date : 2020-01-01 , DOI: 10.1615/critreveukaryotgeneexpr.2020035775
Yuexin Wang 1 , Anna Jia 1 , Yejin Cao 1 , Xuelian Hu 2 , Yufei Wang 1 , Qiuli Yang 1 , Yujing Bi 3 , Guangwei Liu 1
Affiliation  

Mammalian STE20-like protein kinases (MST), including MST1, MST2, MST3, and MST4, belong to the germinal center kinase (GCK) family. Kinase MST1/2 is an important component of the Hippo pathway in regulating cell proliferation, tissue homeostasis, and organ development. Recent studies have shown that Hippo kinase MST1/2 plays a crucial role in immune-associated diseases, which has attracted extensive attention of researchers. This review summarizes recent research on Hippo kinases MST1/2 in regulating the function of immune cells in innate and adaptive immune systems, and also includes its regulatory role and significance in cancer, infection, and autoimmune diseases.

中文翻译:

河马激酶MST1 / 2调节癌症,感染和自身免疫性疾病中的免疫细胞功能

包括MST1,MST2,MST3和MST4在内的哺乳动物STE20样蛋白激酶(MST)属于生发中心激酶(GCK)家族。激酶MST1 / 2是河马途径中调节细胞增殖,组织稳态和器官发育的重要组成部分。最近的研究表明,河马激酶MST1 / 2在免疫相关疾病中起着至关重要的作用,引起了研究人员的广泛关注。这篇综述总结了关于河马激酶MST1 / 2在调节先天性和适应性免疫系统中免疫细胞功能方面的最新研究,还包括其在癌症,感染和自身免疫性疾病中的调节作用和意义。
更新日期:2020-01-01
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