Vacancy engineering is a robust strategy to tune nanomaterials’ electronic structures for physicochemical properties regulation. Here, we report and realize the first oxygen vacancy-enhanced photothermal and oxidation dual-induced synergistic tumour therapy using oxygen vacancies enriched MnO₂@Au nanoconstructs as the therapeutic agent with a high photothermal effect, enhanced highly-toxic superoxide radical generation, good biocompatibility and tumour microenvironment regulation capacity. Our work opens up a new route for cancer nanotheranostics by regulating the electronic structure of nanomaterials resulting in enhanced efficacy.

中文翻译：

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氧空位增强的光热性能和活性氧的产生，用于协同肿瘤治疗。

空缺工程是调整纳米材料的电子结构以调节其理化性质的有效策略。在这里，我们报告并实现了第一个以氧空位富集的MnO ₂ @Au纳米结构作为氧治疗剂的光氧增强光热和氧化双重诱导的协同肿瘤治疗，具有高光热效应，增强的高毒性超氧化物自由基生成，良好的生物相容性和肿瘤微环境调节能力。我们的工作通过调节纳米材料的电子结构，从而提高了疗效，为癌症纳米热学开辟了一条新途径。