当前位置: X-MOL 学术Biomater. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A call for action to the biomaterial community to tackle antimicrobial resistance.
Biomaterials Science ( IF 6.6 ) Pub Date : 2020-08-21 , DOI: 10.1039/d0bm01160f
Thomas J Hall 1 , Victor M Villapún 1 , Owen Addison 2 , Mark A Webber 3 , Morgan Lowther 1 , Sophie E T Louth 1 , Sophie E Mountcastle 1 , Mathieu Y Brunet 1 , Sophie C Cox 1
Affiliation  

The global surge of antimicrobial resistance (AMR) is a major concern for public health and proving to be a key challenge in modern disease treatment, requiring action plans at all levels. Microorganisms regularly and rapidly acquire resistance to antibiotic treatments and new drugs are continuously required. However, the inherent cost and risk to develop such molecules has resulted in a drying of the pipeline with very few compounds currently in development. Over the last two decades, efforts have been made to tackle the main sources of AMR. Nevertheless, these require the involvement of large governmental bodies, further increasing the complexity of the problem. As a group with a long innovation history, the biomaterials community is perfectly situated to push forward novel antimicrobial technologies to combat AMR. Although this involvement has been felt, it is necessary to ensure that the field offers a united front with special focus in areas that will facilitate the development and implementation of such systems. This paper reviews state of the art biomaterials strategies striving to limit AMR. Promising broad-spectrum antimicrobials and device modifications are showcased through two case studies for different applications, namely topical and implantables, demonstrating the potential for a highly efficacious physical and chemical approach. Finally, a critical review on barriers and limitations of these methods has been developed to provide a list of short and long-term focus areas in order to ensure the full potential of the biomaterials community is directed to helping tackle the AMR pandemic.

中文翻译:

呼吁生物材料界采取行动应对抗菌素耐药性。

全球抗菌素耐药性(AMR)激增是公共卫生的主要问题,并且被证明是现代疾病治疗中的关键挑战,需要各级行动计划。微生物定期且迅速获得对抗生素治疗的抵抗力,因此不断需要新药。但是,开发此类分子的内在成本和风险已导致管道干燥,目前正在开发的化合物很少。在过去的二十年中,已努力解决AMR的主要来源。然而,这些需要大型政府机构的参与,进一步增加了问题的复杂性。作为一个有着悠久创新历史的团体,生物材料界处于完美的位置,可以推动新型抗菌技术来对抗AMR。尽管已经感受到了这种参与,但有必要确保该领域提供统一的战线,并特别侧重于有利于此类系统的开发和实施的领域。本文回顾了努力限制AMR的最新生物材料策略。通过针对不同应用的两个案例研究,即局部用药和植入物,展示了广谱的抗菌剂和设备的改进前景,证明了高效物理和化学方法的潜力。最后,已经对这些方法的障碍和局限性进行了严格的审查,以提供短期和长期重点领域的清单,以确保生物材料界的全部潜力被用于帮助应对AMR大流行。有必要确保该领域提供统一的战线,特别侧重于有利于此类系统的开发和实施的领域。本文回顾了努力限制AMR的最新生物材料策略。通过针对不同应用的两个案例研究,即局部用药和植入物,展示了广谱的抗菌剂和设备的改进前景,证明了高效物理和化学方法的潜力。最后,已经对这些方法的障碍和局限性进行了严格的审查,以提供短期和长期重点领域的清单,以确保生物材料界的全部潜力被用于帮助应对AMR大流行。有必要确保该领域提供统一的战线,特别侧重于有利于此类系统的开发和实施的领域。本文回顾了努力限制AMR的最新生物材料策略。通过针对不同应用的两个案例研究,即局部用药和植入物,展示了广谱的抗菌剂和设备的改进前景,证明了高效物理和化学方法的潜力。最后,已经对这些方法的障碍和局限性进行了严格的审查,以提供短期和长期重点领域的清单,以确保生物材料界的全部潜力被用于帮助应对AMR大流行。
更新日期:2020-09-15
down
wechat
bug