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Neurological complications with COVID-19: A contemporaneous review
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_596_20 Boby Varkey Maramattom 1, 2 , Siddharth Bhattacharjee 1, 2
The COVID-19 pandemic is raging across the world, affecting 212 Countries and Territories around the world. It has infected more than 3.7 million people with a mortality rate of around 7%. Although the causative virus, the SARS-CoV-2 is primarily a respiratory pathogen, recent observational studies have documented a high rate of neurological complications associated with COVID-19. We searched PubMed databases from December 01, 2019 to June 9, 2020 for articles published on “COVID 19” OR “coronavirus” with targeted search words. We also search preprint servers for neurological complications of COVID-19. Neurological manifestations are seen in around 36%–45% of patients with COVID-19 and can involve almost every part of the central nervous system (CNS) from the hemispheres, cranial or peripheral nerves, spinal cord, and muscle. The mechanisms vary from direct viral invasion of the CNS, to a dysregulated host immune response to molecular mimicry to multiorgan dysfunction. In many patients, neurological manifestations preceded other systemic features or the diagnosis of COVID-19. Sick patients with COVID-19 will require ICU care and many patients may present first to the neurocritical care ICU and receive a diagnosis of COVID-19 later. Hence, it is important for all healthcare personnel to be aware of the myriad neurological manifestations of this infection, so as to initiate appropriate infection control practices and refine investigation and treatment protocols.
中文翻译：
COVID-19 的神经系统并发症：同期回顾
新冠肺炎 (COVID-19) 疫情正在全球肆虐，影响全球 212 个国家和地区。它已感染超过 370 万人，死亡率约为 7%。尽管致病病毒 SARS-CoV-2 主要是一种呼吸道病原体，但最近的观察性研究记录了与 COVID-19 相关的神经系统并发症的发生率很高。我们在 2019 年 12 月 1 日至 2020 年 6 月 9 日期间检索了 PubMed 数据库，以查找发表在“COVID 19”或“冠状病毒”上的具有针对性搜索词的文章。我们还搜索预印本服务器以了解 COVID-19 的神经系统并发症。大约 36%–45% 的 COVID-19 患者会出现神经系统症状，几乎涉及中枢神经系统 (CNS) 的每个部分，包括半球、颅神经或周围神经、脊髓和肌肉。其机制各不相同，从病毒直接侵入中枢神经系统，到对分子拟态的宿主免疫反应失调，再到多器官功能障碍。在许多患者中，神经系统表现先于其他全身特征或诊断出 COVID-19。患有 COVID-19 的患者将需要 ICU 护理，许多患者可能会先到神经重症监护 ICU 就诊，然后再接受 COVID-19 的诊断。因此，所有医护人员都必须了解这种感染的多种神经系统表现，以便采取适当的感染控制措施并完善调查和治疗方案。
更新日期：2020-08-21
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_596_20 Boby Varkey Maramattom 1, 2 , Siddharth Bhattacharjee 1, 2
Affiliation
The COVID-19 pandemic is raging across the world, affecting 212 Countries and Territories around the world. It has infected more than 3.7 million people with a mortality rate of around 7%. Although the causative virus, the SARS-CoV-2 is primarily a respiratory pathogen, recent observational studies have documented a high rate of neurological complications associated with COVID-19. We searched PubMed databases from December 01, 2019 to June 9, 2020 for articles published on “COVID 19” OR “coronavirus” with targeted search words. We also search preprint servers for neurological complications of COVID-19. Neurological manifestations are seen in around 36%–45% of patients with COVID-19 and can involve almost every part of the central nervous system (CNS) from the hemispheres, cranial or peripheral nerves, spinal cord, and muscle. The mechanisms vary from direct viral invasion of the CNS, to a dysregulated host immune response to molecular mimicry to multiorgan dysfunction. In many patients, neurological manifestations preceded other systemic features or the diagnosis of COVID-19. Sick patients with COVID-19 will require ICU care and many patients may present first to the neurocritical care ICU and receive a diagnosis of COVID-19 later. Hence, it is important for all healthcare personnel to be aware of the myriad neurological manifestations of this infection, so as to initiate appropriate infection control practices and refine investigation and treatment protocols.
中文翻译：
COVID-19 的神经系统并发症：同期回顾
新冠肺炎 (COVID-19) 疫情正在全球肆虐，影响全球 212 个国家和地区。它已感染超过 370 万人，死亡率约为 7%。尽管致病病毒 SARS-CoV-2 主要是一种呼吸道病原体，但最近的观察性研究记录了与 COVID-19 相关的神经系统并发症的发生率很高。我们在 2019 年 12 月 1 日至 2020 年 6 月 9 日期间检索了 PubMed 数据库，以查找发表在“COVID 19”或“冠状病毒”上的具有针对性搜索词的文章。我们还搜索预印本服务器以了解 COVID-19 的神经系统并发症。大约 36%–45% 的 COVID-19 患者会出现神经系统症状，几乎涉及中枢神经系统 (CNS) 的每个部分，包括半球、颅神经或周围神经、脊髓和肌肉。其机制各不相同，从病毒直接侵入中枢神经系统，到对分子拟态的宿主免疫反应失调，再到多器官功能障碍。在许多患者中，神经系统表现先于其他全身特征或诊断出 COVID-19。患有 COVID-19 的患者将需要 ICU 护理，许多患者可能会先到神经重症监护 ICU 就诊，然后再接受 COVID-19 的诊断。因此，所有医护人员都必须了解这种感染的多种神经系统表现，以便采取适当的感染控制措施并完善调查和治疗方案。
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