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Bone Marrow Concentrate in the Treatment of Aneurysmal Bone Cysts: A Case Series Study.
Stem Cells International ( IF 4.3 ) Pub Date : 2020-08-21 , DOI: 10.1155/2020/8898145
Lorenzo Andreani 1 , Sheila Shytaj 1 , Elisabetta Neri 1 , Fabio Cosseddu 1 , Antonio D'Arienzo 1 , Rodolfo Capanna 1
Affiliation  

Introduction. A recent attractive option regarding mesenchymal stem cells (MSC) application is the treatment of bone cystic lesions and in particular aneurysmal bone cysts (ABC), in order to stimulate intrinsic healing. We performed a retrospective evaluation of the results obtained at our institution. Methods. The study group consisted of 46 cases with an average follow-up of 33 months. Forty-two patients underwent percutaneous treatment as the first approach; four patients had curettage as first treatment. In all cases, autologous bone marrow concentrate (BMC) was associated too. The healing status was followed up through a plain radiograph 45 days and 2 months after the procedure. Results and Conclusions. At the final follow-up, thirty-six patients healed with a Neer type II aspect, nine healed with a type I aspect, and one patient was not classified having total hip arthroplasty. Bone marrow concentrate is easy to obtain and to manipulate and can be immediately available in a clinical setting. We can assert that the use of BMC must be encouraged being harmless and having an unquestionable high osteogenic and healing potential in bone defects.

中文翻译:

骨髓浓缩物治疗动脉瘤性骨囊肿:病例系列研究。

简介。最近关于间充质干细胞 (MSC) 应用的一个有吸引力的选择是治疗骨囊性病变,特别是动脉瘤性骨囊肿 (ABC),以刺激内在愈合。我们对在我们机构获得的结果进行了回顾性评估。方法。研究组46例,平均随访33个月。42名患者接受了第一种方法经皮治疗;4名患者进行了刮宫作为第一次治疗。在所有情况下,自体骨髓浓缩物(BMC)也相关。术后 45 天和 2 个月通过 X 线平片跟踪愈合状态。结果和结论。在最后的随访中,36 名患者愈合为 Neer II 型,9 名患者愈合为 I 型,1 名患者未分类为全髋关节置换术。骨髓浓缩物很容易获得和操作,并且可以在临床环境中立即获得。我们可以断言,必须鼓励使用 BMC 是无害的,并且在骨缺损中具有无可置疑的高成骨和愈合潜力。
更新日期:2020-08-21
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