SR/RS domains are found in almost all eukaryotic genomes from C. elegans to human. These domains are thought to mediate interactions between proteins but also between proteins and RNA in complex networks associated with mRNA splicing, chromatin structure, transcription, cell cycle and cell structure. A precise and tight regulation of their function is achieved through phosphorylation of a number of serine residues within the SR/RS motifs by the Serine-Arginine protein kinases (SRPKs) that lead to delicate structural alterations. Given that coronavirus N proteins also contain SR/RS domains, we formulate the hypothesis that the viruses exploit the properties of these motifs to promote unpacking of viral RNA and virion assembly.

几乎在所有真核生物基因组中都发现了SR / RS结构域 秀丽隐杆线虫对人类。这些结构域被认为可以介导蛋白质之间的相互作用，也可以介导蛋白质与RNA之间复杂的网络中的相互作用，这些网络与mRNA剪接，染色质结构，转录，细胞周期和细胞结构有关。通过丝氨酸-精氨酸蛋白激酶（SRPK）对SR / RS基序中的许多丝氨酸残基进行磷酸化，可以实现对它们功能的精确而严格的调节。鉴于冠状病毒N蛋白也包含SR / RS结构域，我们提出以下假设：病毒利用这些基序的特性来促进病毒RNA的解包和病毒体装配。