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Circadian variations in plasma concentrations of cholecystokinin and gastrin in man.
Scandinavian Journal of Clinical and Laboratory Investigation ( IF 2.1 ) Pub Date : 2020-08-21 , DOI: 10.1080/00365513.2020.1804072
Jens F Rehfeld 1 , Henriette P Sennels 2 , Henrik L Jørgensen 3 , Jan Fahrenkrug 2
Affiliation  

Abstract

Cholecystokinin (CCK) is a gut hormone which regulates gallbladder contraction and pancreatic enzyme secretion. In addition, CCK is also a major intestinal satiety signal. The knowledge about CCK in circulation, however, has been limited by difficulties in accurate measurement of the concentrations in plasma. Thus, CCK circulates in low concentrations and furthermore, it is structurally homologous to the antral hormone, gastrin, which circulates in higher concentrations. Therefore, most antibodies raised against CCK cross-react in immunoassays with gastrin. However, using highly sensitive and entirely specific in-house radioimmunoassays, which meet these challenges, we have now measured the daily concentration-variations of CCK and gastrin in plasma from young healthy men (n = 24). Plasma was sampled every third hour from each person during 24 h. The results show that the gastrointestinal secretion of both CCK and gastrin in man display significant circadian variations.



中文翻译:

人体内胆囊收缩素和胃泌素血浆浓度的昼夜节律变化。

摘要

胆囊收缩素 (CCK) 是一种肠道激素,可调节胆囊收缩和胰酶分泌。此外,CCK也是肠道饱腹感的主要信号。然而,关于循环中 CCK 的知识由于难以准确测量血浆中的浓度而受到限制。因此,CCK 以低浓度循环,此外,它在结构上与以较高浓度循环的胃窦激素胃泌素同源。因此,大多数针对 CCK 的抗体在与胃泌素的免疫测定中发生交叉反应。然而,使用高度敏感和完全特异性的内部放射免疫测定法来应对这些挑战,我们现在已经测量了年轻健康男性血浆中 CCK 和胃泌素的每日浓度变化(n = 24)。在 24 小时内,每三小时从每个人身上采集血浆样本。结果表明,人的CCK和胃泌素的胃肠道分泌表现出显着的昼夜节律变化。

更新日期:2020-08-21
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