Phytochemical investigation of the rhizome of Ligusticum chuanxiong Hort led to the isolation and identification of three new compounds, chuanxiongoside A, (2E,4E)-8-(6-O-inositolyl)-8-oxo-2,7-dimethyl-octadienoic acid (2), chuanxiongoside C (3). The structures of these compounds were unambiguously established by HR-ESI-MS, UV, IR, CD, NMR spectral data and comparison to reported data. All the isolated compounds (1–3) were investigated for their inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells. All compounds showed excellent inhibition of NO production stronger than curcumin.

中文翻译：

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川gust中的三种新化合物及其抗炎活性。

川gust的根茎的植物化学研究导致分离和鉴定了三种新化合物，川x甙A，（2 E，4 E）-8-（6- O-肌醇基）-8-oxo-2,7-二甲基-辛二烯酸（2），川x子苷C（3）。这些化合物的结构通过HR-ESI-MS，UV，IR，CD，NMR光谱数据以及与报告数据的比较而明确建立。所有的分离的化合物（1 - 3）进行了调查对一氧化氮（NO）产生的LPS诱导的RAW 264.7细胞的抑制作用。所有化合物对姜黄素的抑制作用均强于姜黄素。