Abstract

A new flavonol named 5,4'-dihydroxy-6,7-[(1''S,2''R)-1''-hydroxy-2''-(1-hydroxy-1-methylethyl)-furano]flavonol (1), together with eight known compounds (2–9), were isolated from the seeds of Psoralea corylifolia. Their chemical structures were elucidated on the basis of spectroscopic analyses. In addition, all compounds were firstly studied for their proliferation effects on osteoblastic-like UMR 106 cells. Results showed that compounds 1, 2, 5 and 8 possessed significant promoting effects on cell proliferation and increased osteoblastic cell numbers by 26.3%, 34.6%, 20.5% and 21.1% at concentrations of 10⁻⁸ M, 10⁻⁸ M, 10⁻¹⁰ M and 10⁻¹⁰ M, respectively. These data indicated that flavonoids may be the main constituents accounting for the bone protective effects of the seeds of P. corylifolia.

摘要

一种名为5,4'-二羟基-6,7-[(1'' S ,2'' R )-1''-羟基-2''-(1-羟基-1-甲基乙基)-呋喃的新黄酮醇]黄酮醇 ( 1 ) 与八种已知化合物 ( 2-9 ) 一起从Psoralea corylifolia的种子中分离出来。在光谱分析的基础上阐明了它们的化学结构。此外，首先研究了所有化合物对成骨细胞样 UMR 106 细胞的增殖作用。结果表明，化合物1，2，5和8具有对细胞增殖显著促进作用和26.3％，34.6％，20.5％和21增加成骨细胞的数量。^-8 M、10 ^-8 M、10 ^-10 M 和10 ^-10 M 分别。这些数据表明，黄酮类化合物可能是造成P. corylifolia种子骨骼保护作用的主要成分。