Synthesis ( IF 2.6 ) Pub Date : 2020-08-20 , DOI: 10.1055/s-0040-1707247 Christina Moberg 1
Abstract
Bismetalated alkenes, accessible by element–element addition to alkynes, are valuable building blocks in organic synthesis, providing wide opportunities for divergent synthesis. Silaboration of alkynes with a pendant olefinic group, catalyzed by group 10 metal complexes, and subsequent transformation of the silicon and boron functional groups give access to densely functionalized 1,3-dienes and 1,3,5-trienes with defined stereo- and regiochemistry, 1,2-dienes, and carbocyclic and heterocyclic products.
1 Introduction
2 Background
3 Reactions with 1,3-Enynes
4 Cyclization 1,6-Enynes
5 Cyclization 1,7-Enynes
6 Cyclization of 1,n-Enynes (n > 7)
7 Cyclization of Dienynes and Enediynes
8 Cyclization of 1,6-Diynes
9 Conclusions
中文翻译:
甲硅烷基硼烷作为有机合成的有力工具:与1,n-烯炔的立体和区域选择性反应
摘要
双炔金属可以通过炔烃中的元素-元素添加而获得,是有机合成中的重要组成部分,为发散合成提供了广泛的机会。通过第10组金属配合物催化的具有悬垂的烯基的炔烃的硅烷化反应以及随后的硅和硼官能团的转化可实现具有定义的立体和区域化学反应的稠密官能化的1,3-二烯和1,3,5-三烯,1,2-二烯以及碳环和杂环产品。
1引言
2背景
与1,3-烯炔反应3
4环化1,6-Enynes
5环化1,7-Enynes
1,n-Enynes的6个环化(n> 7)
7 Dienynes和Enediyneynes的环化
1,6-二炔的8环化
9结论