Abstract

α-Regio- and diastereoselective (3+2) cycloadditions of nitrone ylides derived from isatins with activated alkenes have been demonstrated. This mild protocol allows rapid access to a wide range of 3′,5′-diaryl-1′-hydroxy-2-oxospiro[indoline-3,2′-pyrrolidine] derivatives by using DABCO as an efficient catalyst. This method could also be carried out through three-component reaction efficiently in good yields and excellent diastereoselectivity.

中文翻译：

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DABCO催化来自靛红和活化烯烃的硝基叶立德的α-区域和非对映选择性（3 + 2）环加成反应

摘要

已证明衍生自靛红与活性烯烃的亚硝酰基内酰胺的α-区域和非对映选择性（3 + 2）环加成反应。通过使用DABCO作为有效催化剂，该温和的操作方案可以快速访问3，，5'-二芳基-1'-羟基-2-氧代螺螺[二氢吲哚-3,2'-吡咯烷]衍生物。该方法也可以通过三组分反应以高收率和优异的非对映选择性有效地进行。