The 1,3‐dipolar cycloaddition reactions (DCs) of nitrile oxides (NOs) to alkenes and alkynes are useful methods for the synthesis of 2‐isoxazolines and isoxazoles respectively, which are important classes of heterocyclic compounds in organic and medicinal chemistry. Most of these reactions are carried out in organic solvents and under thermal activation. Nevertheless the use of supercritical carbon dioxide (scCO₂) and ionic liquids (Ils) as alternative solvents and the application of microwave (MW) and ultrasound (US) as alternative activation procedures have evident advantages from the “Green Chemistry” point of view. The critical discussion on the applications of these “unconventional” activation methods and reaction conditions in the 1,3‐DCs of NOs is the objective of the present Review.

中文翻译：

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在“非常规”条件下，氧化腈的1,3-偶极环加成反应：绿色溶剂，辐射和连续流动

腈类化合物（NOs）与烯烃和炔烃的1,3-偶极环加成反应（DCs）是分别合成2-异恶唑啉和异恶唑的有用方法，它们是有机和药物化学中的重要杂环化合物。这些反应大多数在有机溶剂中并在热活化下进行。然而，从“绿色化学”的角度来看，使用超临界二氧化碳（scCO ₂）和离子液体（Ils）作为替代溶剂以及使用微波（MW）和超声（US）作为替代活化程序具有明显的优势。关于这些“非常规”活化方法和反应条件在NOs的1,3-DC中的应用的批判性讨论是本综述的目的。