A major challenge in fish physiology is to understand the mechanisms underlying the transcriptomic responses of fish brain to food deprivation. Differential gene expression analysis identified in total 2240 transcripts that presented >2-fold change (adjusted p < 0.01) between each treatment and the control group (C). The identity of the transcripts was obtained with annotation against multiple public databases and they were grouped according to their expression patterns. The gene ontology terms that were substantially affected were identified by functional annotation analysis. Genes related to ion transport, cell cycle and cell adhesion were mainly regulated during fasting and refeeding. These findings contribute to identify key indicators for the molecular basis of brain functions during periods of starvation in gilthead seabream.

鱼生理学的主要挑战是了解鱼脑对食物剥夺的转录反应的潜在机制。差异基因表达分析鉴定出总共2240个转录本，表现出> 2倍的变化（调整后的p  <  0.01），介于各治疗组和对照组（C）之间。转录本的身份是通过对多个公共数据库的注释获得的，并根据它们的表达方式进行分组。通过功能注释分析可以确定受到实质影响的基因本体术语。与离子转运，细胞周期和细胞粘附有关的基因主要在禁食和再喂养期间受到调控。这些发现有助于确定银头鲷在饥饿期间脑功能分子基础的关键指标。