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Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors.
Virchows Archiv ( IF 3.5 ) Pub Date : 2020-08-20 , DOI: 10.1007/s00428-020-02909-2
Yuemei Xu 1, 2 , Zhiwen Li 1 , Jiong Shi 1 , Yao Fu 1 , Li Zhu 3 , Xiangshan Fan 1 , Wen-Chi Foo 2
Affiliation  

Mesenchymal tumors of the prostate are rare but encompass a wide differential diagnosis. In our study, we aimed to investigate the clinicopathological features that can be used to differentiate malignant solitary fibrous tumors (mSFTs) occurring in the prostate from prostatic stromal tumors. A total of 15 patients with mesenchymal tumors of the prostate were identified in Nanjing Drum Tower Hospital from 2009 to 2019, including 3 mSFTs, 9 stromal tumors of uncertain malignant potential (STUMPs), and 3 prostatic stromal sarcomas (PSSs). Immunohistochemical stains for signal transducer and activator of transcription 6 (STAT6), aldehyde dehydrogenase 1 (ALDH1), CD34, desmin, smooth muscle actin (SMA), progesterone receptor (PR), CD117, and cytokeratin (CK) were performed on representative sections from each tumor, and the clinical features, histology, and immunophenotype of these three groups were analyzed. There was no significant difference in mean patient age of patients diagnosed with mSFTs, STUMPs, and PSSs. mSFTs and PSSs showed significantly increased tumor size (p < 0.05), Ki-67 proliferation index (p < 0.0001), and mitotic activity (p < 0.05) when compared with STUMPs. mSFTs showed significantly higher expression of STAT6 compared with both PSSs and STUMPs (p < 0.0001, p < 0.0001). PR showed significantly more expression in STUMPs than in mSFTs or PSSs (p < 0.0001, p < 0.0001). Desmin and SMA showed significantly more expression in STUMPs than in mSFTs (p < 0.05). ALDH1, CD117, CK, and CD34 showed no significant difference in staining between mSFTs, STUMPs, and PSSs. Therefore, a limited panel of STAT6, PR, and Ki-67 may be useful in distinguishing between mSFTs, STUMPs, and PSSs.



中文翻译:

区分前列腺恶性孤立性纤维性肿瘤和前列腺间质瘤的临床病理特征。

前列腺的间质肿瘤很少见,但涵盖了广泛的鉴别诊断。在我们的研究中,我们旨在研究可用于区分前列腺中发生的恶性孤立性纤维性肿瘤(mSFTs)与前列腺间质瘤的临床病理特征。从2009年至2019年,南京鼓楼医院共鉴定了15例前列腺间质瘤患者,包括3例SFT,9例恶性潜能不确定的间质瘤和3例前列腺间质肉瘤(PSS)。在代表性的切片上进行了信号转导和转录激活因子6(STAT6),醛脱氢酶1(ALDH1),CD34,结蛋白,平滑肌肌动蛋白(SMA),孕激素受体(PR),CD117和细胞角蛋白(CK)的免疫组织化学染色。从每个肿瘤,临床特征,组织学,并分析了这三组的免疫表型。诊断为mSFT,STUMP和PSS的患者的平均患者年龄没有显着差异。mSFT和PSS显示出明显的肿瘤大小( 与STUMP相比,p  <0.05),Ki-67增殖指数(p  <0.0001)和有丝分裂活性(p <0.05)。与PSS和STUMP相比,mSFTs显着提高STAT6的表达(p  <0.0001,p  <0.0001)。PR显示STUMP中的表达明显高于mSFTs或PSS中的表达(p  <0.0001,p  <0.0001)。Desmin和SMA在STUMP中的表达明显高于在mSFT中的表达(p  <0.05)。ALDH1,CD117,CK和CD34在mSFT,STUMP和PSS之间的染色上没有显着差异。因此,STAT6,PR和Ki-67的限定面板可能有助于区分mSFT,STUMP和PSS。

更新日期:2020-08-21
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