Five new chromone methide polymers, (±)-amplisins A–D (1–4) and amplisin E (5), were isolated from a new fungicolous fungus Amplistroma fungicola. Compounds 1–5 were determined to have unusual chemical skeletons with two or three chromone methide groups linked with different polyketides. A non-enzymatic 1,4-Michael addition of chromone methide was verified in the biosynthesis of 1–5. Compounds 1 and 2 showed inhibition of PTP1B and stimulation of glucose uptake in insulin-resistant HepG2 cells. Compounds 3–5 exhibited strong NO inhibition of LPS-activated macrophages.

中文翻译：

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Amplisins A–E，一种新的真菌性真菌Amplistroma fungicola具有降血糖活性的甲基苯甲酸酯色聚合物

从一种新的真菌木耳菌Amplistroma fungicola中分离出了五种新的甲基苯醌甲基聚合物（±）-amplisins A–D（1-4）和amplisin E（5）。化合物1-5被确定具有不寻常的化学骨架，带有两个或三个色酮甲基与不同的聚酮相连。在1–5的生物合成中，验证了非酶促1,4-Michael色酮的添加。化合物1和2在胰岛素抵抗性HepG2细胞中显示出对PTP1B的抑制作用和对葡萄糖摄取的刺激。化合物3-5对LPS活化的巨噬细胞表现出强烈的NO抑制作用。