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11C- and 18F-labelled tryptophans as PET-tracers for imaging of altered tryptophan metabolism in age-associated disorders
Russian Chemical Reviews ( IF 7.7 ) Pub Date : 2020-08-04 , DOI: 10.1070/rcr4954
Boris D. Zlatopolskiy 1, 2, 3 , Heike Endepols 1, 2, 4 , Raisa N. Krasikova 5 , Olga S. Fedorova 5 , Johannes Ermert 1 , Bernd Neumaier 1, 2, 3
Affiliation  

The ageing of the world’s population is the result of increased life expectancy observed in almost all countries throughout the world. Consequently, a rising tide of ageing-associated disorders, like cancer and neurodegenerative diseases, represents one of the main global challenges of the 21st century. The ability of mankind to overcome these challenges is directly dependent on the capability to develop novel methods for therapy and diagnosis of age-associated diseases. One hallmark of age-related pathologies is an altered tryptophan metabolism. Numerous pathological processes including neurodegenerative and neurological diseases like epilepsy, Parkinson’s and Alzheimer’s diseases, cancer and diabetes exhibit marked changes in tryptophan metabolism. Visualization of key processes of tryptophan metabolic pathways, especially using positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI, can be exploited to early detect the aforementioned disorders with considerable accuracy, allowing appropriate and timely treatment of patients. Here we review the published 11C- and 18F-labelled tryptophans with respect to the production and also preclinical and clinical evaluation as PET-tracers for visualization of different branches of tryptophan metabolism.

The bibliography includes 159 references.



中文翻译:

11C 和 18F 标记的色氨酸作为 PET 示踪剂,用于对年龄相关疾病中色氨酸代谢改变的成像

世界人口的老龄化是世界上几乎所有国家都观察到预期寿命延长的结果。因此,与衰老相关的疾病(如癌症和神经退行性疾病)呈上升趋势,代表了 21 世纪的主要全球挑战之一。人类克服这些挑战的能力直接取决于开发用于治疗和诊断与年龄相关的疾病的新方法的能力。与年龄相关的病理的一个标志是色氨酸代谢改变。许多病理过程,包括神经退行性和神经系统疾病,如癫痫、帕金森病和阿尔茨海默病、癌症和糖尿病,都表现出色氨酸代谢的显着变化。色氨酸代谢途径关键过程的可视化,特别是使用正电子发射断层扫描 (PET) 和相关的混合方法,如 PET/CT 和 PET/MRI,可用于早期检测上述疾病,并具有相当高的准确性,从而可以对患者进行适当和及时的治疗。在这里我们回顾已发布的11 C 和18 F 标记的色氨酸作为 PET 示踪剂的生产以及临床前和临床评估,用于可视化色氨酸代谢的不同分支。

参考书目包括 159 篇参考文献。

更新日期:2020-08-04
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