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Carcinogenic and neurotoxic risks of dietary acrylamide consumed through cereals among the Lebanese population.
BMC Chemistry ( IF 4.6 ) Pub Date : 2020-08-19 , DOI: 10.1186/s13065-020-00705-2
Areej Merhi 1 , Ghada El-Zakhem Naous 1 , Ralph Daher 1 , Martine Abboud 2 , Mohamad Mroueh 3 , Robin I Taleb 1
Affiliation  

The present study aims to determine the carcinogenic and neurotoxic risks associated with acrylamide intake from cereal products. Analysis on a UPLC–MS/MS spectrometer revealed that oat-based and mixed cereals contain the highest amount of acrylamide among cereal products with levels as high as 271 and 348 μg/kg, respectively. Children were shown to exhibit both carcinogenic and neurotoxic risks regardless of the type of cereal product consumed. For adults above 50 years of age, only consumers of oat-based cereal products seem to exhibit carcinogenic and neurotoxic risks. To avoid a carcinogenic and neurotoxic risk among the Lebanese population, we propose that food processors set the maximum tolerable concentration for acrylamide in cereal products at 94.8 μg/kg product, a value which is threefolds lower than the average acrylamide levels found in this study. Alternatively, and unreasonably, the average Lebanese population and children among the Lebanese population may choose to cut down on cereal consumption by 1.7- and 7.2-folds respectively, should they want to avoid a health hazard as a result of acrylamide intake. The industry should also respond by optimizing the production process in a way to reduce acrylamide levels in cereals.

中文翻译:

黎巴嫩人口通过谷物摄入的膳食丙烯酰胺具有致癌和神经毒性风险。

本研究旨在确定与从谷物产品中摄入丙烯酰胺相关的致癌和神经毒性风险。UPLC-MS/MS 光谱仪分析显示,燕麦类谷物和混合谷物中丙烯酰胺含量最高,分别高达 271 微克/千克和 348 微克/千克。无论食用哪种谷物产品,儿童都表现出致癌和神经毒性风险。对于 50 岁以上的成年人来说,似乎只有燕麦谷物产品的消费者才会表现出致癌和神经毒性风险。为了避免黎巴嫩人口出现致癌和神经毒性风险,我们建议食品加工商将谷物产品中丙烯酰胺的最大耐受浓度设定为 94.8 微克/千克产品,该值比本研究中发现的平均丙烯酰胺水平低三倍。另外,如果黎巴嫩平均人口和黎巴嫩人口中的儿童想要避免因摄入丙烯酰胺而造成健康危害,他们可能会选择分别减少 1.7 倍和 7.2 倍的谷物消费,这是不合理的。该行业还应通过优化生产过程来降低谷物中的丙烯酰胺含量。
更新日期:2020-08-20
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