By using dopamine (DA) as the monomer, the model drug avermectin (AVM) was loaded on polydopamine microspheres (AVM/PDAMS) and polydopamine microcapsules (AVM@PDAMC) by the method of impregnation and encapsulation, respectively. The materials’ structures were systematically characterized using Fourier transform infrared spectroscopy (FTIR), zeta potential analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The comparison of antiultraviolet capability as well as release behaviors under different pH values of the materials were studied. The results showed that a spherical appearance was observed from both materials. The use of AVM/PDAMS and AVM@PDAMC made the decomposition temperature of AVM increase to 235°C and 245°C, respectively. After being exposed to ultraviolet light for 1400 min, the residual ratios of AVM of AVM/PDAMS and AVM@PDAMC were 42% and 54%, respectively. Both AVM/PDAMS and AVM@PDAMC showed acid sensitivity. AVM/PDAMS and AVM@PDAMC took about 13 h and 60 h to reach the release rate of 50% under pH 3. The release process of AVM/PDAMS could be explained by the Weibull model at pH 3, while the release behavior of AVM@PDAMC fitted the Baker–Lonsdale equation. At pH 7 and pH 9, both of the delivery materials followed the Korsmeyer–Peppas model and belonged to the Fick diffusion.

中文翻译：

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聚多巴胺/阿维菌素微胶囊与微球抗紫外线和缓释性能的比较研究

以多巴胺（DA）为单体，分别通过浸渍和包封的方法将模型药物阿维菌素（AVM）装载在聚多巴胺微球（AVM / PDAMS）和聚多巴胺微胶囊（AVM @ PDAMC）上。使用傅里叶变换红外光谱（FTIR），ζ电位分析，扫描电子显微镜（SEM），热重分析（TGA）和差示扫描量热法（DSC）对材料的结构进行了系统表征。研究了材料在不同pH值下抗紫外线性能以及释放行为的比较。结果表明，两种材料均观察到球形外观。AVM / PDAMS和AVM @ PDAMC的使用使AVM的分解温度分别提高到235°C和245°C。紫外光照射1400min后，AVM / PDAMS和AVM @ PDAMC的AVM残留率分别为42％和54％。AVM / PDAMS和AVM @ PDAMC均显示出酸敏感性。在pH 3下，AVM / PDAMS和AVM @ PDAMC分别花费了大约13 h和60 h达到50％的释放速率。在pH 3下，Weibull模型可以解释AVM / PDAMS的释放过程，而AVM的释放行为@PDAMC拟合了贝克-朗斯代尔方程。在pH为7和pH 9时，两种输送材料均遵循Korsmeyer-Peppas模型，并且属于Fick扩散。在pH 3时，Weibull模型可以解释AVM / PDAMS的释放过程，而AVM @ PDAMC的释放行为符合贝克-朗斯代尔方程。在pH为7和pH 9时，两种输送材料均遵循Korsmeyer-Peppas模型，并且属于Fick扩散。在pH 3时，Weibull模型可以解释AVM / PDAMS的释放过程，而AVM @ PDAMC的释放行为符合贝克-朗斯代尔方程。在pH为7和pH 9时，两种输送材料均遵循Korsmeyer-Peppas模型，并且属于Fick扩散。