Diabetic retinopathy (DR) is defined as a microvascular pathology. However, some data have suggested that the retinal photoreceptors (PRs) might be important in the pathogenesis of this ocular disease. In this study the organization of the PRs in control and diabetic-induced rats was compared using multiphoton microscopy. The PR mosaic was imaged at different locations in non-stained retinas. The density of PRs was directly quantified from cell counting. The spatially resolved density presents a double-slope pattern (from the central retina towards the periphery) in both healthy and pathological samples, although the values for the latter were significantly lower all across the retina. Moreover, Voronoi analysis was performed to explore changes in PR topography. In control specimens a hexagonally packed structure was dominant. However, despite the non-controlled effects of the disease in retinal structures, this PR regularity was fairly maintained in diabetic retinas.

中文翻译：

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用多光子显微镜成像的糖尿病大鼠模型中光感受器镶嵌的排列

糖尿病性视网膜病（DR）被定义为微血管病变。但是，一些数据表明，视网膜光感受器（PRs）在这种眼病的发病机理中可能很重要。在这项研究中，使用多光子显微镜比较了对照组和糖尿病诱导的大鼠中PR的组织。PR马赛克在未染色的视网膜中的不同位置成像。从细胞计数直接定量PRs的密度。尽管健康和病理样本的空间分辨密度均呈双斜率模式（从中央视网膜向外围），但后者的值在整个视网膜上均显着降低。此外，进行了Voronoi分析以探索PR地形的变化。在对照样品中，六方堆积的结构占主导。然而，