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Innovative optofluidics and microscopy-based rapid analysis of pathogens
Biomedical Optics Express ( IF 3.4 ) Pub Date : 2020-08-17 , DOI: 10.1364/boe.396345
Hao Wang , Priyanka Shiveshwarkar , Robert Brzozowski , Arseny Zhdanov , Shulin Shi , Prahathees Eswara , Anna Pyayt

The timely knowledge and prescription of the most suitable antibiotic to treat bacterial infections is critical for the recovery of patients battling life-threatening bacterial infections. Unfortunately, current standard-of-care approaches relies on the empiric prescription of an antibiotic, as determination of the most effective antibiotic requires multiple time-consuming steps. These steps often include culturing of the bacterium responsible for infection and subsequent antibiotic susceptibility testing. Here we introduce an optofluidic technology that allows us to capture bacterial cells efficiently and rapidly from different biological samples and use the captured cells for rapid antibiotic selection thereby bypassing the need to culture the bacterium.

中文翻译:

创新的光流体学和基于显微镜的病原体快速分析

及时了解最合适的抗生素以治疗细菌感染,这对于抵抗威胁生命的细菌感染的患者的康复至关重要。不幸的是,当前的护理标准方法依赖于抗生素的经验性处方,因为确定最有效的抗生素需要多个耗时的步骤。这些步骤通常包括培养负责感染的细菌和随后的抗生素敏感性测试。在这里,我们介绍了一种光流体技术,该技术使我们能够从不同的生物样本中高效快速地捕获细菌细胞,并将捕获的细胞用于快速抗生素选择,从而无需培养细菌。
更新日期:2020-09-01
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