Functional single-cell liver hemi-canaliculi have been generated in a synthetic microenvironment using a reductionist approach. It is shown that the interaction between the extracellular matrix and static cadherin is sufficient to develop an apicobasal polarity independently of the contact with neighbouring cells.

中文翻译：

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顶端无相邻细胞。

使用还原论方法，在合成的微环境中已产生功能性单细胞肝半小管。结果表明，细胞外基质与静态钙黏着蛋白之间的相互作用足以独立于与相邻细胞的接触而形成apapobasal极性。