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Serum levels of inflammasome pathway factors in clinically isolated syndrome and multiple sclerosis patients: a pilot study
Central European Journal of Immunology ( IF 1.3 ) Pub Date : 2020-07-09 , DOI: 10.5114/ceji.2020.96877
Yusuf Tamam , Hande Yüceer , Berna Düzel , Melis Şen , Canan Ulusoy , Erdem Tuzun

Pathogenic roles of nuclear factor kB (NF-kB) pathway and NLRP3 inflammasome complex factors are involved in multiple sclerosis (MS) development. Activation of the NF-kB, NLRP3, and caspase-1 cascade results in production of proinflammatory cytokines that lead to stimulation of macrophages, lymphocytes, and glial cells. Although increased levels of inflammasome complex factors are observed in MS, contribution of inflammasome pathway to conversion from clinically isolated syndrome (CIS) to relapsing remitting MS (RRMS) has been scarcely investigated. To examine predictive value of inflammasome factors in CIS-MS conversion, levels of NLRP3, caspase-1, and NFkB are measured by ELISA in sera of age-gender matched CIS (n = 18; 8 converting, 10 non-converting) and RRMS (n = 23) patients. CIS and RRMS patients have comparable serum levels of NLRP3, caspase-1, and NFkB. Similarly, no statistically significant difference can be found among converting and nonconverting CIS patients by means of inflammasome complex factor levels. Inflammasome factors are presumably overexpressed at early stages of MS. Therefore, they are unlikely to be used as biomarkers to predict CIS-MS conversion.

中文翻译:

临床孤立综合征和多发性硬化症患者血清炎性体通路因子水平:一项初步研究

核因子kB(NF-kB)途径和NLRP3炎性体复杂因子的致病作用与多发性硬化(MS)的发展有关。NF-kB,NLRP3和caspase-1级联反应的激活导致促炎细胞因子的产生,从而刺激巨噬细胞,淋巴细胞和神经胶质细胞。尽管在MS中观察到了炎性体复杂因子水平的升高,但很少研究炎性体途径对从临床孤立综合征(CIS)转变为复发缓解型MS(RRMS)的作用。为了检查炎症因子在CIS-MS转化中的预测价值,通过ELISA在年龄性别匹配的CIS(n = 18; 8个转化,10个非转化)和RRMS血清中测量了NLRP3,caspase-1和NFkB的水平。 (n = 23)位患者。CIS和RRMS患者的血清NLRP3水平相当,caspase-1和NFkB。同样,通过炎症小体复杂因子水平,在转化和未转化的CIS患者之间也没有发现统计学上的显着差异。炎性体因子可能在MS的早期过表达。因此,它们不太可能用作预测CIS-MS转化的生物标记。
更新日期:2020-08-20
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