Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition. However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.

中文翻译：

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烟曲霉中铜调节剂 Mac1 缺乏对铁获取的调节。

烟曲霉是侵袭性曲霉病的最常见原因，这是一种威胁生命的感染，主要影响免疫功能低下的患者。基本金属铜和铁在这种霉菌的毒力中起着至关重要的作用。最近，据报道，铜调节转录因子 Mac1 还参与控制铁的获取。然而，在目前的研究中，无论是固体和液体培养基上的生长试验、铁载体产生的分析还是参与铁获取的基因的表达分析都表明 Mac1 参与了烟曲霉铁吸收的调节。