Abstract Multicomponent reaction of 2-nitroacetophenone, urotropine (or paraformaldehyde), β-dicarbonyl compound and ammonium acetate afforded five new 4-unsubstituted 5-nitro-6-phenyl-1,4-dihydropyridine derivatives, oxidation of which provided the corresponding 5-nitro-6-phenylpyridines. The proposed approach for the synthesis of 4-unsubstituted 5-nitro-6-phenyl-1,4-dihydropyridines and their subsequent aromatization into pyridines made it possible to reduce the total reaction time by more than 200 times and the overall yield of 5-nitro-6-phenylpyridine by 2 times compared with the known methods. Graphical Abstract

中文翻译：

---

4-未取代的5-硝基吡啶衍生物的多组分合成

摘要 2-硝基苯乙酮、乌洛托品（或多聚甲醛）、β-二羰基化合物和醋酸铵的多组分反应得到了五种新的4-未取代的5-硝基-6-苯基-1,4-二氢吡啶衍生物，氧化得到相应的5-硝基-6-苯基吡啶。所提出的合成 4-未取代 5-硝基-6-苯基-1,4-二氢吡啶及其随后芳构化为吡啶的方法可以将总反应时间缩短 200 倍以上，并提高 5-硝基-6-苯基吡啶比已知方法高2倍。图形概要