Abstract Triazolophanes with benzophenone and S(-)-BINOL functionalization at the intra annular position have been synthesized by the click reaction of 4,4′-bis(azidomethyl) benzophenone with the corresponding bispropargyloxy compounds. The newly synthesized triazolophanes were characterized by spectral and analytical methods. Triazolophane with S(-)-BINOL and benzophenone functionality at the intra annular position shows good target binding ability in molecular docking studies and also better antibacterial activity against all the four tested pathogens viz. Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium, and Escherichia coli bacteria. Graphical Abstract

中文翻译：

---

环内位置具有二苯甲酮和 S(-)-BINOL 官能化的三唑啉的合成、表征、抗菌活性和分子对接研究

摘要 通过 4,4'-双(叠氮甲基)二苯甲酮与相应的双炔丙氧基化合物的点击反应合成了在环内位置具有二苯甲酮和 S(-)-BINOL 官能化的三唑啉。新合成的三唑啉通过光谱和分析方法进行了表征。在环内位置具有 S(-)-BINOL 和二苯甲酮官能团的三唑啉在分子对接研究中显示出良好的靶标结合能力，并且对所有四种测试病原体也具有更好的抗菌活性，即。金黄色葡萄球菌、枯草芽孢杆菌、鼠伤寒沙门氏菌和大肠杆菌。图形概要