当前位置: X-MOL 学术Synth. Commun. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Asymmetric α-hydroxylation of β-dicarbonyl compounds by C-2′ modified cinchonine-derived phase-transfer catalysts in batch and flow microreactors
Synthetic Communications ( IF 2.1 ) Pub Date : 2020-06-24 , DOI: 10.1080/00397911.2020.1781183
Xiao-Fei Tang 1, 2 , Jing-Nan Zhao 1 , Yu-Feng Wu 1 , Ze-Hao Zheng 1 , Cun-Fei Ma 1 , Zong-Yi Yu 1 , Lei Yun 1 , Guang-Zhi Liu 1 , Qing-Wei Meng 1
Affiliation  

Abstract The asymmetric α-hydroxylation of β-dicarbonyl compounds was catalyzed by C-2′-modified cinchonine-derived phase-transfer catalysts. Excellent yields (up to 95%) and good enantioselectivities (up to 89% ee) were obtained. The reaction was carried out in a flow microreactor and similar results were obtained (up to 93% yield, 84% ee), the residence time was shortened from 24 h in batch to 2 h. Graphical Abstract

中文翻译:

C-2'修饰的辛可宁衍生相转移催化剂在间歇和流动微反应器中对β-二羰基化合物进行不对称α-羟基化

摘要 β-二羰基化合物的不对称α-羟基化是由C-2'-修饰的辛可宁衍生的相转移催化剂催化的。获得了优异的产率(高达 95%)和良好的对映选择性(高达 89% ee)。该反应在流动微反应器中进行,获得了相似的结果(产率高达 93%,ee 为 84%),停留时间从分批的 24 小时缩短到 2 小时。图形概要
更新日期:2020-06-24
down
wechat
bug