Abstract Spironucleosides are a type of conformationally restricted bicycle nucleoside analogous in which the carbocyclic/heterocyclic ring is inserted at carbohydrate moiety of the nucleoside and this restrict the conformational flexibility of the carbohydrate ring. Hydantocidin is the first naturally occurring spironucleoside which shows potent herbicidal and plant growth regulatory activities. The biological activity of hydantocidin has encouraged the synthetic organic chemist to synthesize constrained nucleosides analogous for drug discovery. We present here an overview of the synthesis and biological importance of C-4′-spironucleoside analogous. Graphical Abstract

中文翻译：

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C-4′-螺核苷的合成新进展及展望

摘要 螺核苷是一类受构象限制的自行车核苷类似物，其中碳环/杂环插入核苷的碳水化合物部分，这限制了碳水化合物环的构象灵活性。Hydantocidin 是第一种天然存在的螺核苷，显示出有效的除草和植物生长调节活性。hydantocidin 的生物活性鼓励合成有机化学家合成类似药物发现的受限核苷。我们在此概述了 C-4'-螺核苷类似物的合成和生物学重要性。图形概要