Abstract 2H-1,2,3-Benzothiadiazine 1,1-dioxides are a class of compounds of pharmacological interest. After earlier studies carried out at our laboratory on various transformations (alkylation, acylation, and reduction) at the hetero ring, the present paper focuses on the transformation of substituents at the aromatic carbocycle, including nucleophilic substitution of chlorine atoms and demethylation of the methoxy group with amines. The new methods described here allow the introduction of versatile functional groups on the aromatic ring, making these compounds useful building blocks for organic and medicinal chemistry applications. Graphical Abstract

中文翻译：

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2H-1,2,3-苯并噻二嗪 1,1-二氧化物通过亲核取代和去甲基化反应在芳环上被不同取代

摘要 2H-1,2,3-苯并噻二嗪1,1-二氧化物是一类具有药理意义的化合物。在我们实验室对杂环上的各种转化（烷基化、酰化和还原）进行了较早的研究后，本文重点研究了芳族碳环上取代基的转化，包括氯原子的亲核取代和甲氧基的去甲基化与胺。这里描述的新方法允许在芳环上引入多功能官能团，使这些化合物成为有机和药物化学应用的有用构建块。图形概要