ABSTRACT

Human skin melanoma is one of the most aggressive and difficult to treat human malignancies, with an increasing incidence over the years. While the resection of the early diagnosed primary tumor remains the best clinical approach, advanced/metastatic melanoma still remains with a poor prognosis. Indeed, although enormous progress in the therapeutic treatment of human tumors has been made in recent years, patients affected by metastatic melanoma are still poorly affected by these clinical advances. Therefore, new valuable therapeutic approaches are urgently needed, to design and define effective treatments to consistently increase the overall survival rate of patients affected by this malignancy. In this review we summarize the main signaling pathways studied to kill human skin melanoma, and introduce the ferroptotic cell death as a new pathway to be explored to eradicate this tumor.

摘要

人类皮肤黑色素瘤是最具侵袭性和最难治疗的人类恶性肿瘤之一，近年来发病率不断增加。虽然切除早期诊断的原发肿瘤仍然是最好的临床方法，但晚期/转移性黑色素瘤的预后仍然较差。事实上，尽管近年来人类肿瘤的治疗取得了巨大进展，但受转移性黑色素瘤影响的患者仍然很少受到这些临床进展的影响。因此，迫切需要新的有价值的治疗方法来设计和定义有效的治疗方法，以持续提高受这种恶性肿瘤影响的患者的总体生存率。在这篇综述中，我们总结了研究杀死人类皮肤黑色素瘤的主要信号通路，并介绍了铁死亡细胞死亡作为根除这种肿瘤的新途径。