Abstract

Practical and efficient synthesis of phthalimides compounds 3 were described and characterized. The synthesized compounds were screened for their antimicrobial activities against gram-positive bacterial strains (Micrococcus luteus, Listeria monocytogenes, Staphylococcus aureus and Bacillus cereus), a gram-negative bacterial strain (Salmonella typhimurium) and a fungus (Candida albicans). Cytotoxicity studies of the of phthalimides 3 were conducted in two human cancer cell lines, MDA-MB-231 and MCF-7.

中文翻译：

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邻苯二甲酰亚胺的高效合成及其生物活性

摘要

描述和表征了邻苯二甲酰亚胺化合物3的实用和有效合成。筛选了合成的化合物对革兰氏阳性菌株（微球菌、李斯特菌、金黄色葡萄球菌和蜡状芽孢杆菌）、革兰氏阴性菌株（鼠伤寒沙门氏菌）和真菌（白色念珠菌）的抗菌活性。邻苯二甲酰亚胺3的细胞毒性研究在两种人类癌细胞系MDA-MB-231和MCF-7中进行。