Abstract

Mesoporous silica nanoparticles (MSNPs) are a particular example of innovative nanomaterials for the development of drug delivery systems. MSNPs have recently received more attention for biological and pharmaceutical applications due to their capability to deliver therapeutic agents. Due to their unique structure, they can function as an effective carrier for the delivery of therapeutic agents to mitigate diseases progress, reduce inflammatory responses and consequently improve cancer treatment. The potency of MSNPs for the diagnosis and management of various diseases has been studied. This literature review will take an in-depth look into the properties of various types of MSNPs (e.g. shape, particle and pore size, surface area, pore volume and surface functionalisation), and discuss their characteristics, in terms of cellular uptake, drug delivery and release. MSNPs will then be discussed in terms of their therapeutic applications (passive and active tumour targeting, theranostics, biosensing and immunostimulative), biocompatibility and safety issues. Also, emerging trends and expected future advancements of this carrier will be provided.

摘要

介孔二氧化硅纳米粒子 (MSNP) 是用于开发药物递送系统的创新纳米材料的一个特殊例子。由于 MSNP 具有递送治疗剂的能力，它们最近在生物和药物应用中受到更多关注。由于其独特的结构，它们可以作为治疗药物的有效载体，以减轻疾病的进展，减少炎症反应，从而改善癌症治疗。已经研究了 MSNP 在诊断和管理各种疾病方面的效力。这篇文献综述将深入研究各种类型的 MSNP 的特性（例如形状、颗粒和孔径、表面积、孔体积和表面功能化），并讨论它们在细胞摄取方面的特性，药物递送和释放。然后将讨论 MSNP 的治疗应用（被动和主动肿瘤靶向、治疗诊断学、生物传感和免疫刺激）、生物相容性和安全性问题。此外，还将提供该载体的新兴趋势和预期未来发展。