New thermosensitive hydrogels based on N‐isopropyl acrylamide and 2‐hydroxyethyl acrylate were prepared in the presence of ammonium persulfate as an initiator using a free‐radical technique. The thermal stability as well as the physical and chemical properties of the obtained hydrogel were studied by thermogravimetric analysis, differential scanning calorimetry and scanning electron microscopy. The swelling of the hydrogels was investigated by the cathetometer method. In order to use thermosensitive hydrogels as a carrier of antibiotics (lincomycin and gentamicin), several biological tests were performed. All samples of thermosensitive poly(N‐isopropyl acrylamide) and 2‐hydroxyethyl acrylate hydrogels containing medical substances exhibited antibacterial activity. The antibacterial activity of temperature‐sensitive hydrogels naturally increases with increasing concentration of antibiotics in the carrier. The results obtained indicate a large amount of drug was released from the hydrogels with full retention of antimicrobial properties. These copolymers can be used as an antibacterial material in the field of medicine. © 2020 Society of Chemical Industry

中文翻译：

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基于N-异丙基丙烯酰胺和丙烯酸2-羟乙酯的水凝胶：合成，表征和研究其抗菌活性

在过硫酸铵作为引发剂的情况下，采用自由基技术制备了基于N-异丙基丙烯酰胺和丙烯酸2-羟乙酯的新型热敏水凝胶。通过热重分析，差示扫描量热法和扫描电子显微镜研究了所得水凝胶的热稳定性以及理化性质。水凝胶的溶胀通过导管计法进行研究。为了使用热敏水凝胶作为抗生素（林可霉素和庆大霉素）的载体，进行了一些生物学测试。所有热敏聚（N含异丙醇的异丙醇）和含有医用物质的丙烯酸2-羟乙酯的水凝胶均具有抗菌活性。温度敏感性水凝胶的抗菌活性自然会随着载体中抗生素浓度的增加而增加。获得的结果表明，大量的药物从水凝胶中释放出来，并充分保留了抗菌特性。这些共聚物可以在医学领域中用作抗菌材料。©2020化学工业协会