Abstract In this study, pH responsive carboxylic cellulose acetate nanoparticles (CCA NPs) have been evaluated as drug nanocarriers for controlled release of drug. Herein, carboxylic cellulose acetate (CCA) was initially synthesized via oxidation of cellulose using a 2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl (TEMPO) as an oxidant and followed by the acetylation of carboxylic cellulose in the presence of iodine as a catalyst. CCA NPs were then obtained via the nanoprecipitation process and subsequent sonication. The obtained CCA NPs with a mean diameter of 96 nm were subsequently evaluated as drug delivery nanocarriers. Penicillin G as a model drug was loaded onto the CCA NPs via the adsorption process. Drug release profiles of Penicillin G from CCA NPs were evaluated in phosphate buffer solution (PBS) at different medium pH values (1.2, 7.4, and 8.6). Release kinetic models were applied to determine the release mechanism of penicillin G from loaded CCA NPs. Results showed that pH-responsive release of penicillin G from CCA NPs which was released most slowly at medium of pH 7.4.

中文翻译：

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用于控制释放青霉素 G 的 pH 响应性羧基醋酸纤维素纳米粒子

摘要 在这项研究中，pH 响应羧基醋酸纤维素纳米粒子 (CCA NPs) 已被评估为药物纳米载体的药物控释。在此，醋酸纤维素 (CCA) 最初是通过使用 2,2,6,6-四甲基哌啶-1-基)氧烷基 (TEMPO) 作为氧化剂氧化纤维素，然后在纤维素存在下乙酰化而合成的。碘作催化剂。然后通过纳米沉淀过程和随后的超声处理获得 CCA NP。随后将获得的平均直径为 96 nm 的 CCA NPs 评估为药物递送纳米载体。青霉素 G 作为模型药物通过吸附过程加载到 CCA NPs 上。在磷酸盐缓冲溶液 (PBS) 中，在不同的介质 pH 值 (1.2、7.4、和 8.6)。应用释放动力学模型来确定青霉素 G 从加载的 CCA NP 中的释放机制。结果表明，青霉素 G 从 CCA NPs 的 pH 响应释放，其在 pH 7.4 的介质中释放最慢。