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Polylactic Acid Microparticles Embedded Porous Gelatin Scaffolds with Multifunctional properties for Soft Tissue Engineering
Journal of Science: Advanced Materials and Devices ( IF 7.382 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jsamd.2020.07.002
Patcharakamon Nooeaid , Piyachat Chuysinuan , Chalinan Pengsuk , Decha Dechtrirat , Kriengsak Lirdprapamongkol , Supanna Techasakul , Jisnuson Svasti

Abstract Suitable three-dimensional scaffolds showing controllable drug delivery properties, known as multifunctional scaffolds, have gained increasing interest for soft tissue engineering. Here, tetracycline hydrochloride-encapsulated polylactic acid (TCH-PLA) microparticles prepared by using the double emulsion/solvent evaporation method were incorporated into a gelatin matrix. Highly interconnected porous TCH-PLA-in-Gel scaffolds were formed by using lyophilization. In vitro release studies showed that the scaffolds exhibit a controlled release behavior and release low amounts of the drug. TCH-PLA particles additionally reinforced porous gelatin scaffolds and enhanced thermal stability. Antibacterial activity of the scaffolds against Staphylococcus aureus and Escherichia coli was confirmed by using the disk diffusion method. The scaffolds exhibited biocompatibility with adult human dermal fibroblasts, without cytotoxicity. Results indicated that TCH-PLA-in-Gel scaffolds showing multifunctional properties are good candidates for the applications of soft tissue engineering.

中文翻译:

用于软组织工程的具有多功能特性的聚乳酸微粒嵌入多孔明胶支架

摘要 具有可控药物递送特性的合适的三维支架,称为多功能支架,在软组织工程中越来越受到关注。在这里,通过使用双乳液/溶剂蒸发方法制备的盐酸四环素包封的聚乳酸(TCH-PLA)微粒被加入到明胶基质中。通过使用冻干形成高度互连的多孔 TCH-PLA-in-Gel 支架。体外释放研究表明,支架表现出控释行为并释放少量药物。TCH-PLA 颗粒还增强了多孔明胶支架并增强了热稳定性。支架对金黄色葡萄球菌和大肠杆菌的抗菌活性通过圆盘扩散法得到证实。支架表现出与成人真皮成纤维细胞的生物相容性,没有细胞毒性。结果表明,具有多功能特性的 TCH-PLA-in-Gel 支架是软组织工程应用的良好候选者。
更新日期:2020-09-01
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