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Messages from the Fourth International Conference on Clinical Metagenomics.
Microbes and Infection ( IF 5.8 ) Pub Date : 2020-08-20 , DOI: 10.1016/j.micinf.2020.07.007
Yannick Charretier 1 , Vladimir Lazarevic 1 , Jacques Schrenzel 2 , Etienne Ruppé 3
Affiliation  

In recent years, clinical metagenomics (CMg), defined as the application of metagenomic sequencing of clinical samples to retrieve clinically relevant data, has evolved dramatically. Following this trend, the Fourth International Conference on Clinical Metagenomics (ICCMg4) was held in Geneva (Switzerland) on 17-18 October 2019. During these two days, several aspects of CMg were addressed and we propose to summarize these in the present paper. Similar to previous editions, the most recent bioinformatic developments of interest for CMg were reported. In addition, four speakers brought CMg to the highest level of resolution by their presentations on coping with strain-level metagenomics, while another speaker illustrated how artificial intelligence could be connected to CMg. Regarding concrete applications, the use of CMg in bone and joint infections, lower respiratory tract infections, endocarditis and viral infections were addressed in a series of lectures. Finally, a round table discussion and dedicated presentations were organized to drive forward the implementation of CMg and promote the exploration of novel avenues for further research.



中文翻译:

第四届临床基因组学国际会议的致辞。

近年来,临床宏基因组学(CMg)(定义为对临床样品进行宏基因组测序以检索临床相关数据的应用)已发生了巨大变化。遵循这一趋势,第四届国际临床基因组学国际会议(ICCMg4)于2019年10月17日至18日在日内瓦(瑞士)举行。在这两天中,对CMg的几个方面进行了讨论,我们建议在本文中进行总结。与以前的版本相似,报道了CMg感兴趣的最新生物信息学发展。此外,四位发言人通过应对应变水平宏基因组学的演讲,将CMg带到了最高的分辨率,而另一位发言人则说明了如何将人工智能与CMg联系起来。关于具体应用,一系列讲座探讨了CMg在骨骼和关节感染,下呼吸道感染,心内膜炎和病毒感染中的使用。最后,组织了一次圆桌讨论会和专门的演讲,以推动CMg的实施,并促进探索进一步研究的新途径。

更新日期:2020-08-20
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