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Clinical manifestations and radiological features by chest computed tomographic findings of a novel coronavirus disease-19 pneumonia among 92 patients in Japan
Journal of Microbiology, Immunology and Infection ( IF 7.4 ) Pub Date : 2020-08-20 , DOI: 10.1016/j.jmii.2020.07.011
Nobuhiro Asai 1 , Daisuke Sakanashi 2 , Akiko Nakamura 2 , Takaaki Kishino 3 , Hideo Kato 2 , Mao Hagihara 2 , Arufumi Shiota 1 , Yusuke Koizumi 1 , Yuka Yamagishi 1 , Hiroshige Mikamo 1
Affiliation  

Introduction

The novel coronavirus disease (COVID-19) could cause a severe acute respiratory infectious disease, showing a high mortality rate of 12–45% among cases who required intensive care unit admission. COVID-19 pneumonia

Patients and methods

For the purpose of identifying clinical manifestations and radiological findings of COVID-19 pneumonia, we reviewed all cases of COVID-19 pneumonia which were published by the homepage of the Japanese Association for Infectious Diseases from Feb 5 2020 until April 30 2020, including our cases. All patients were diagnosed based on positive results of the novel coronavirus-real-time RT-PCR with chest computed tomography (CT) findings.

Results

A total of 92 patients were enrolled in this study. The median age was 66 years (range 16–92 years). For all, 50 (54%) were males. The most common underlying disease was hypertension in 32 (36%). Any comorbidity was seen in 60 (67%). The mortality rate was 4 (6%). In terms of clinical symptoms on an initial visit, fever and cough were confirmed in 66 (72%) and 37 (40%). Forty-three (47%) had no respiratory symptoms. As for radiological findings by chest CT scan, ground-glass opacities (GGO)s, peripheral distribution, bilateral lung involvements were seen in 88 (96%), 76 (83%) and 78 (85%), respectively.

Conclusion

It is difficult to diagnose as COVID-19 pneumonia due to poor respiratory symptoms. Chest CT findings typically show GGO, peripheral and bilateral shadows. Patients should have chest CT performed if suspected for early diagnosis and therapeutic intervention, resulting in a favorable outcome and prevention of secondary nosocomial transmitted infection.



中文翻译:

日本92例新型冠状病毒病-19肺炎的胸部CT表现和影像学特征

介绍

新型冠状病毒病 (COVID-19) 可能导致严重的急性呼吸道传染病,在需要入住重症监护病房的病例中,死亡率高达 12-45%。COVID-19肺炎

患者和方法

为了确定 COVID-19 肺炎的临床表现和放射学发现,我们回顾了日本传染病协会主页从 2020 年 2 月 5 日至 2020 年 4 月 30 日公布的所有 COVID-19 肺炎病例,包括我们的病例. 所有患者均基于新型冠状病毒实时 RT-PCR 的阳性结果和胸部计算机断层扫描 (CT) 发现进行诊断。

结果

本研究共招募了 92 名患者。中位年龄为 66 岁(范围 16-92 岁)。总之,50 人(54%)是男性。32 人(36%)最常见的基础疾病是高血压。60 人(67%)出现任何合并症。死亡率为 4 (6%)。就初诊时的临床症状而言,66 例(72%)和 37 例(40%)确诊发热和咳嗽。43 人 (47%) 没有呼吸道症状。至于胸部CT扫描的放射学发现,毛玻璃样混浊(GGO)、外周分布、双肺受累分别见于88(96%)、76(83%)和78(85%)例。

结论

由于呼吸道症状不佳,很难诊断为 COVID-19 肺炎。胸部 CT 表现通常显示 GGO、周围和双侧阴影。如果怀疑早期诊断和治疗干预,患者应该进行胸部 CT,从而获得良好的结果并预防继发性院内传播感染。

更新日期:2020-08-20
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