The effectiveness and efficiency of a cosmetic product depends not only on the active ingredients, but also on the stability of formulation devoted in improving the bio-functionality. Thus, improving the stability of topical applications with vitamin E is important. The study aimed to optimise kenaf seed oil percentage on gel-cream formulations supplemented with palm-based α-tocopherol and determine their physicochemical properties, antioxidant activities, and α-tocopherol content. The samples were produced by high shear homogenisation and subjected to optimisation to obtain the best formulation with good physical stability and antioxidant activities. The antioxidant activities were determined by radical scavenging assays and α-tocopherol content was quantified by ultra-high performance chromatography. Vitamin E gel-cream formulated from 9% kenaf seed oil (S3) was selected based on its stability in viscosity and antioxidant activities. S3, with pH 6.02 showed viscosity value at 6106.3 cP was physically stable. Also, the α-tocopherol obtained for S3 was 9.34 mg/g sample that indicated 3.63 mg TE/g sample and 10.42 mg TE/g sample for diphenyl-1-picrylhydrazyl and 2,2-azino-bis(3-ethylbenzot-hiazoline-6-sulphonic acid) radical scavenging activities, respectively. For 12 weeks storage stability study at 25 ± 2 °C and 40 ± 2 °C, S3 showed good microbial stability but with mild depletion of tocopherol content. Overall, the results herein gathered are very promising towards the development of new cosmetic formulations using kenaf seed oil and palm-based α-tocopherol.

化妆品的有效性和效率不仅取决于活性成分，还取决于致力于改善生物功能的制剂的稳定性。因此，使用维生素E改善局部应用的稳定性很重要。这项研究旨在优化补充了棕榈基α-生育酚的凝胶霜配方上的洋麻籽油百分比，并确定其理化性质，抗氧化活性和α-生育酚含量。通过高剪切均质化生产样品，并进行优化以获得具有良好物理稳定性和抗氧化活性的最佳配方。通过自由基清除测定法测定抗氧化剂活性，并通过超高效色谱法定量α-生育酚含量。根据其粘度稳定性和抗氧化活性，选择了由9％洋麻籽油（S3）配制的维生素E凝胶霜。pH 6.02的S3在6106.3 cP处显示粘度值是物理稳定的。另外，对于S3获得的α-生育酚为9.34mg / g样品，对于二苯基-1-吡啶并肼基和2，2-叠氮基双（3-乙基苯并-噻唑啉）指示为3.63mg TE / g样品和10.42mg TE / g样品。 -6-磺酸）自由基清除活性。在25±2°C和40±2°C下进行12周的储存稳定性研究，S3表现出良好的微生物稳定性，但生育酚含量较轻。总体而言，本文收集的结果对于使用洋麻籽油和棕榈基α-生育酚开发新型化妆品配方非常有希望。