Drug Discovery Today ( IF 7.4 ) Pub Date : 2020-08-20 , DOI: 10.1016/j.drudis.2020.08.004 Jihyeob Mun 1 , Gildon Choi 2 , Byungho Lim 2
Bioinformatics-centric drug development is inevitable in the era of precision medicine. Clinical ‘omics information, including genomics, epigenomics, transcriptomics, and proteomics, provides the most comprehensive molecular landscape in which each patient’s pathological history is delineated. Hence, the capability of bioinformaticians to manage integrative ‘omics data is crucial to current drug development. Bioinformatics can accelerate drug development from initial time-consuming discoveries to the clinical stage by providing information-guided solutions. However, many bioinformaticians do not have opportunities to participate in drug discovery programs. As a starting point for bioinformaticians with no prior drug development experience, here we discuss bioinformatics applications during drug development with a focus on working-level omics-based methodologies.
中文翻译:
生物信息学家指南:“基于组学的精确肿瘤学药物发现。
在精密医学时代,以生物信息学为中心的药物开发是不可避免的。临床组学信息,包括基因组学,表观基因组学,转录组学和蛋白质组学,提供了最全面的分子概况,在其中描述了每个患者的病理史。因此,生物信息学家管理综合组学数据的能力对于当前药物开发至关重要。通过提供信息指导的解决方案,生物信息学可以将药物开发从最初的耗时发现加速到临床阶段。但是,许多生物信息学家没有机会参加药物发现计划。作为没有药物开发经验的生物信息学家的起点,