The up-regulation of PRMT1 is critical to the cell growth and cancer progression of lung cancer cells. In our research, we found that PRMT1 is important to the DNA repair ability and drug resistance of lung cancer cells. To demonstrate the functions of PRMT1, we identified Flap endonuclease 1 (FEN1) as a post-translationally modified downstream target protein of PRMT1. As a major component of Base Excision Repair pathway, FEN1 plays an important role in DNA replication and DNA damage repair. However, the detailed mechanism of FEN1 up-regulation in lung cancer cells remains unclear. In our study, we identified PRMT1 as a key factor that maintains the high expression levels of FEN1, which is critical to the DNA repair ability and the chemotherapeutic drug resistance of lung cancer cells.

PRMT1的上调对于肺癌细胞的细胞生长和癌症进展至关重要。在我们的研究中，我们发现PRMT1对肺癌细胞的DNA修复能力和耐药性很重要。为了证明PRMT1的功能，我们鉴定了Flap内切核酸酶1（FEN1）作为PRMT1的翻译后修饰下游目标蛋白。作为碱基切除修复途径的主要组成部分，FEN1在DNA复制和DNA损伤修复中起着重要作用。然而，肺癌细胞中FEN1上调的详细机制仍不清楚。在我们的研究中，我们确定PRMT1是维持FEN1高表达水平的关键因素，这对肺癌细胞的DNA修复能力和化学治疗耐药性至关重要。