Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively. The structures further revealed the location of Ca²⁺ modulatory site that is likely conserved among several TRP subgroups.

中文翻译：

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揭示了 TRPA1 通道的门控和钙传感机制。

在激动剂碘乙酰胺和拮抗剂 A-967079 的存在下确定了人类 TRPA1 通道的新结构，以分别揭示通道的开放和关闭状态。这些结构进一步揭示了可能在几个 TRP 亚群中保守的 Ca ²⁺调节位点的位置。