Deregulation of nutrient, hormonal, or neuronal signaling produces metabolic alterations that result in increased mitochondrial reactive oxygen species (ROS) production. The associations of the mitochondrial respiratory chain components into supercomplexes could have pathophysiological relevance in metabolic diseases, as supramolecular arrangements, by sustaining a high electron transport rate, might prevent ROS generation. In this review, the relationship between mitochondrial dysfunction and supercomplex arrangement of the mitochondrial respiratory chain components in obesity, insulin resistance, hepatic steatosis and diabetes mellitus is summarized and discussed.

中文翻译：

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代谢疾病中线粒体超复合体装配的改变。

营养素，激素或神经元信号的失控会产生代谢改变，从而导致线粒体活性氧（ROS）产生增加。线粒体呼吸链成分与超复合物的关联在代谢疾病中可能具有病理生理相关性，因为超分子排列通过维持较高的电子传输速率可能会阻止ROS的产生。本文综述并讨论了肥胖，胰岛素抵抗，肝脂肪变性和糖尿病患者线粒体功能障碍与线粒体呼吸链组成的超复杂安排之间的关系。