With the advancing age, there is an increase of the incidence of chronic renal diseases. However, it is suggested that exercise, as resistance training, is a key factor in positively modulate the kidney structure and function. Thus, this study aimed to analyze the effects of estrogen deprivation and a moderate resistance protocol on the right kidney structure of rats. A total of 32 animals were randomly divided in four groups (n = 8/per group): control group (CG); resistance trained animals (RT); control ovariectomized animals (OvxC); and trained ovariectomized animals (OvxT). Sections of the right kidney were stained with hematoxylin and eosin for morphometry and blood was collected for biochemical analysis. Our results showed that the group submitted to both ovariectomy and resistance training had significant impact on renal corpuscle components (Bowman’s space, renal corpuscle area, and visceral layer), and proximal and distal tubules. Additionally, resistance training, with or without estrogen deprivation, increases creatine phosphokinase and decreases ultrasensitive C-reactive protein. In summary, we suggested that moderate resistance training may be a key factor to maintain the kidney structure and function across age. However, future studies are need to corroborate with our findings.

随着年龄的增长，慢性肾病的发病率呈上升趋势。然而，建议运动作为阻力训练，是积极调节肾脏结构和功能的关键因素。因此，本研究旨在分析雌激素剥夺和适度抵抗方案对大鼠右肾结构的影响。共32只动物随机分为四组（n=8/每组）：对照组（CG）；抗性训练动物 (RT)；对照去卵巢动物 (OvxC)；和训练有素的去卵巢动物 (OvxT)。右肾切片用苏木精和伊红染色用于形态测定，并收集血液用于生化分析。我们的结果表明，接受卵巢切除术和阻力训练的组对肾小体成分（鲍曼间隙、肾小体面积和内脏层）以及近端和远端小管有显着影响。此外，无论有无雌激素剥夺，阻力训练都会增加肌酸磷酸激酶并降低超敏 C 反应蛋白。总之，我们认为适度的阻力训练可能是维持肾脏结构和功能的关键因素。然而，未来的研究需要证实我们的发现。我们认为适度的阻力训练可能是维持肾脏结构和功能的关键因素。然而，未来的研究需要证实我们的发现。我们认为适度的阻力训练可能是维持肾脏结构和功能的关键因素。然而，未来的研究需要证实我们的发现。