Silver nanoparticles are highly efficient antibacterial agents. The applications of silver nanoparticles in the biological environment are always obstructed by oxidation that causes aggregation of nanoparticles which lowers its antibacterial activity. In this research, silver nanoparticles were coated on the surface of mesoporous silica forming mesoporous silver nanoshells (Ag@MSNs). The prepared nanoparticles were characterized by their zeta potential, particle size, UV absorption spectroscopy, and transmission electron microscopy. Additionally, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were also performed. The antimicrobial activity of the prepared Ag@MSNs was evaluated against gram-positive and gram-negative pathogens. The results showed that Ag@MSNs are monodispersed with an average size distribution 272 ± 61 nm. Ag@MSNs are highly stable with zeta potential value of 43.3 ± 6.5 mV and an absorption peak at 235 nm. Small-angle X-ray diffraction demonstrated a narrow and strong peak at 2ϴ = 1.71^ο indicating that the Ag@MSNs have an ordered porous structure. Surface coating of mesoporous silica nanoparticles with silver shells increased the contact surface area with the bacterial membrane. Thus, Ag@MSNs significantly inhibited the growth of Staphylococcus aureus and E-coli. In conclusion the present study gives new insights into the synthesis of antimicrobial nano-formulation that can offer a variety of uses in industry and biomedical applications.

银纳米颗粒是高效的抗菌剂。银纳米颗粒在生物环境中的应用总是受到氧化的阻碍，氧化会导致纳米颗粒聚集，从而降低其抗菌活性。在这项研究中，将银纳米颗粒涂覆在介孔二氧化硅的表面上，形成介孔银纳米壳（Ag @ MSNs）。所制备的纳米颗粒通过其ζ电位，粒度，UV吸收光谱和透射电子显微镜表征。此外，还进行了傅里叶变换红外光谱（FTIR），差示扫描量热法（DSC）和X射线衍射（XRD）。评估了制备的Ag @ MSNs对革兰氏阳性和革兰氏阴性病原体的抗菌活性。结果表明，Ag @ MSNs是单分散的，平均粒径分布为272±61 nm。Ag @ MSNs高度稳定，ζ电位值为43.3±6.5 mV，吸收峰位于235 nm。小角X射线衍射在2θ= 1.71处显示出窄而强的峰^ο表示Ag @ MSN具有有序的多孔结构。具有银壳的中孔二氧化硅纳米颗粒的表面涂层增加了与细菌膜的接触表面积。因此，Ag @ MSNs显着抑制金黄色葡萄球菌和大肠杆菌的生长。总而言之，本研究为抗菌纳米配方的合成提供了新的见解，可以在工业和生物医学应用中提供多种用途。