当前位置: X-MOL 学术Open Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Ribosomal proteins: mutant phenotypes by the numbers and associated gene expression changes.
Open Biology ( IF 5.8 ) Pub Date : 2020-08-19 , DOI: 10.1098/rsob.200114
Michael Polymenis 1
Affiliation  

Ribosomal proteins are highly conserved, many universally so among organisms. All ribosomal proteins are structural parts of the same molecular machine, the ribosome. However, when ribosomal proteins are mutated individually, they often lead to distinct and intriguing phenotypes, including specific human pathologies. This review is an attempt to collect and analyse all the reported phenotypes of each ribosomal protein mutant in several eukaryotes (Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Homo sapiens). These phenotypes were processed with unbiased computational approaches to reveal associations between different phenotypes and the contributions of individual ribosomal protein genes. An overview of gene expression changes in ribosomal protein mutants, with emphasis on ribosome profiling studies, is also presented. The available data point to patterns that may account for most of the observed phenotypes. The information presented here may also inform future studies about the molecular basis of the phenotypes that arise from mutations in ribosomal proteins.



中文翻译:

核糖体蛋白:突变表型的数量和相关的基因表达变化。

核糖体蛋白是高度保守的,许多在生物体中普遍如此。所有核糖体蛋白都是同一分子机器核糖体的结构部分。然而,当核糖体蛋白单独发生突变时,它们通常会导致不同且有趣的表型,包括特定的人类病理。这篇综述试图收集和分析几种真核生物(酿酒酵母秀丽隐杆线虫黑腹果蝇兔兔小家鼠智人)中每个核糖体蛋白突变体的所有报告表型。)。这些表型是用无偏见的计算方法处理的,以揭示不同表型之间的关联和单个核糖体蛋白基因的贡献。还介绍了核糖体蛋白突变体中基因表达变化的概述,重点是核糖体分析研究。可用数据指向的模式可能解释了大多数观察到的表型。此处提供的信息还可以为未来关于由核糖体蛋白突变引起的表型的分子基础的研究提供信息。

更新日期:2020-08-19
down
wechat
bug