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A self-assembled cylindrical platform for Plk4-induced centriole biogenesis.
Open Biology ( IF 5.8 ) Pub Date : 2020-08-19 , DOI: 10.1098/rsob.200102
Kyung S Lee 1 , Jung-Eun Park 1 , Jong Il Ahn 1 , Zhuang Wei 1 , Liang Zhang 1
Affiliation  

The centrosome, a unique membraneless multiprotein organelle, plays a pivotal role in various cellular processes that are critical for promoting cell proliferation. Faulty assembly or organization of the centrosome results in abnormal cell division, which leads to various human disorders including cancer, microcephaly and ciliopathy. Recent studies have provided new insights into the stepwise self-assembly of two pericentriolar scaffold proteins, Cep63 and Cep152, into a near-micrometre-scale higher-order structure whose architectural properties could be crucial for proper execution of its biological function. The construction of the scaffold architecture appears to be centrally required for tight control of a Ser/Thr kinase called Plk4, a key regulator of centriole duplication, which occurs precisely once per cell cycle. In this review, we will discuss a new paradigm for understanding how pericentrosomal scaffolds are self-organized into a new functional entity and how, on the resulting structural platform, Plk4 undergoes physico-chemical conversion to trigger centriole biogenesis.



中文翻译:

用于 Plk4 诱导的中心粒生物发生的自组装圆柱形平台。

中心体是一种独特的无膜多蛋白细胞器,在促进细胞增殖的各种细胞过程中起着关键作用。中心体的错误组装或组织会导致细胞分裂异常,从而导致各种人类疾病,包括癌症、小头畸形和纤毛病。最近的研究提供了关于两种中心周支架蛋白 Cep63 和 Cep152 逐步自组装成近微米级高阶结构的新见解,其结构特性对其生物功能的正确执行至关重要。支架结构的构建似乎是严格控制称为 Plk4 的 Ser/Thr 激酶所必需的,Plk4 是中心粒复制的关键调节因子,每个细胞周期恰好发生一次。在这次审查中,

更新日期:2020-08-19
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