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Non-apoptotic roles of apoptotic proteases: new tricks for an old dog.
Open Biology ( IF 5.8 ) Pub Date : 2020-08-19 , DOI: 10.1098/rsob.200130
Tin Tin Su 1, 2
Affiliation  

This Open Question article highlights current advances in the study of non-apoptotic roles of apoptotic proteins. Apoptosis is a highly regulated and energy-requiring process in which cells actively kill themselves. Apoptosis helps remove extra cells to sculpt organs during embryo development and culls damaged cells throughout the body. Apoptosis relies on evolutionarily conserved proteins that include a family of proteases called caspases. Caspases activity has long been considered a hallmark of apoptosis. Yet an emerging body of literature indicates that caspase activity is required for a number of non-lethal processes that range from sculpting cells, removing protein aggregates, changing cell identity during differentiation or de-differentiation, and rebuilding tissues. Failure in each of these processes is associated with human disease. This article is not meant to be an exhaustive review but an introduction to the subject for an educated public, with caspases as a gateway example. I propose that it is time to explore non-apoptotic roles of caspases and other apoptotic proteins, in order to better understand their non-apoptosis function and to leverage new knowledge into new therapies.



中文翻译:

凋亡蛋白酶的非凋亡作用:老狗的新技巧。

这篇未解决的问题文章重点介绍了凋亡蛋白非凋亡作用研究的最新进展。细胞凋亡是一个高度调节且需要能量的过程,在该过程中细胞会主动杀死自己。细胞凋亡有助于在胚胎发育过程中去除多余的细胞以塑造器官,并剔除全身受损的细胞。细胞凋亡依赖于进化上保守的蛋白质,其中包括称为 caspase 的蛋白酶家族。Caspase 活性长期以来被认为是细胞凋亡的标志。然而,越来越多的文献表明,许多非致命过程都需要半胱天冬酶活性,这些过程包括雕刻细胞、去除蛋白质聚集体、在分化或去分化过程中改变细胞身份以及重建组织。这些过程中的每一个失败都与人类疾病有关。本文并不是详尽的评论,而是针对受过教育的公众对该主题的介绍,并以 caspase 作为入门示例。我建议现在是探索半胱天冬酶和其他凋亡蛋白的非凋亡作用的时候了,以便更好地了解它们的非凋亡功能并将新知识用于新疗法。

更新日期:2020-08-19
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