Different from the traditional role of a Brønsted base, amines/imines have been widely employed during the past few decades as a Lewis base to activate electrophilic allene, olefin, and carbonyl compounds. Understanding the detailed mechanisms and the origin of chemo- and stereo-selectivities for these types of reactions should be very important and highly desirable. In this minireview, the recent advances and methods for analysis of the origin of the selectivities of novel Lewis base amine/imine-mediated reactions are systematically summarized and reviewed from a theoretical viewpoint. This information provides valuable insights for understanding the general action modes of Lewis base amine/imine catalysts and rational design of more efficient organocatalytic reactions with high stereoselectivity and special chemoselectivity.

中文翻译：

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新型路易斯碱胺/亚胺催化反应的理论综述。

与布朗斯台德碱的传统作用不同，胺/亚胺在过去的几十年中被广泛用作路易斯碱来活化亲电性烯，烯烃和羰基化合物。了解这些类型反应的详细机理以及化学和立体选择性的起源应该非常重要并且非常需要。在这篇小型综述中，系统地总结和综述了从理论上对新型路易斯碱胺/亚胺介导的反应的选择性进行分析的最新进展和方法。该信息为理解路易斯碱胺/亚胺催化剂的一般作用模式以及合理设计具有更高立体选择性和特殊化学选择性的更有效的有机催化反应提供了宝贵的见解。