Compared to traditional drug delivery systems, DNA nanostructure-based drug delivery systems have several advantages including programmable sequences, precise size and shape, high drug payloads, excellent biocompatibility and biodegradability. To date, a wide range of chemotherapeutic drug–DNA hybrid nanostructures have been developed for anti-tumor therapy. In this review, the constructions of various DNA nanostructures for anticancer drug delivery are firstly summarized. Next, the anticancer drug loading methods for DNA nanostructures are presented. Then, the recent applications of chemotherapeutic drug–DNA hybrid nanostructures for drug delivery are highlighted. In the end, the challenges and opportunities of the chemotherapeutic drug–DNA hybrid nanostructure-based delivery system are discussed. The designs of drug–DNA hybrid systems, including the constructions of nanostructures and the strategies for drug loading, largely influence the efficiency of drug delivery. Recent studies have focused on the development of novel drug–DNA hybrid systems to acquire more precise and efficient therapy for various diseases. A systematic review of the design strategies of chemotherapeutic drug–DNA hybrid nanostructures will benefit the innovation and development of the chemotherapeutic drug-based chemotherapy in clinics.

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用于抗肿瘤治疗的化疗药物-DNA混合纳米结构

与传统的药物递送系统相比，基于 DNA 纳米结构的药物递送系统具有多个优点，包括可编程序列、精确的尺寸和形状、高药物有效载荷、优异的生物相容性和生物降解性。迄今为止，已经开发出多种化疗药物-DNA混合纳米结构用于抗肿瘤治疗。在这篇综述中，首先总结了用于抗癌药物递送的各种DNA纳米结构的构建。接下来，介绍了用于 DNA 纳米结构的抗癌药物装载方法。然后，重点介绍了化学治疗药物-DNA混合纳米结构在药物递送中的最新应用。最后，讨论了基于化学治疗药物-DNA混合纳米结构的递送系统的挑战和机遇。药物-DNA混合系统的设计，包括纳米结构的构建和药物装载策略，在很大程度上影响药物输送的效率。最近的研究集中在开发新的药物-DNA混合系统，以获得对各种疾病的更精确和有效的治疗。对化疗药物-DNA混合纳米结构设计策略的系统评价将有利于临床化疗药物化疗的创新和发展。