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Chiral Catalysts Utilized in the Nucleophilic Addition of Dialkyl-zinc Reagents to Carbonyl Compounds
Letters in Organic Chemistry ( IF 0.8 ) Pub Date : 2020-07-31 , DOI: 10.2174/1570178617666191220145038
Adnan Cetin 1
Affiliation  

The aim of this review is an overview of diverse dialkyl zinc pro-chiral aldehydes addition reactions. One way of conducting asymmetric reactions is through the use of chiral catalyst. Therefore, new chiral ligands have attracted considerable attention in organic chemistry. Carbon-carbon bond formation reactions are an active research topic. The addition of dialkyl zinc to pro-chiral aldehydes is one of these popular reactions. Also, the chiral amino alcohols are important substrates for drug synthesis. These chiral ligands can be prepared by a simple synthetic way from easily accessible starting materials. This article reviews current catalyst reactions with the addition of dialkyl zinc to carbonyl compounds.



中文翻译:

在二烷基锌试剂与羰基化合物的亲核加成中使用的手性催化剂

这篇综述的目的是概述各种二烷基锌前手性醛加成反应。进行不对称反应的一种方式是通过使用手性催化剂。因此,新的手性配体在有机化学中引起了相当大的关注。碳-碳键形成反应是一个活跃的研究主题。将二烷基锌加到手性醛中是这些流行的反应之一。而且,手性氨基醇是药物合成的重要底物。这些手性配体可以通过容易获得的起始原料通过简单的合成方法来制备。本文回顾了当前的催化剂反应,即在羰基化合物中添加了二烷基锌。

更新日期:2020-07-31
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