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Gastrointestinal manifestations of COVID-19 in children: a systematic review and meta-analysis
Frontline Gastroenterology Pub Date : 2021-07-01 , DOI: 10.1136/flgastro-2020-101529
Anthony K Akobeng 1, 2 , Ciaran Grafton-Clarke 3 , Ibtihal Abdelgadir 2, 4 , Erica Twum-Barimah 5 , Morris Gordon 6
Affiliation  

Objectives To summarise the published evidence on the gastrointestinal manifestations of COVID-19 in children and to determine the prevalence of gastrointestinal symptoms. Methods In this systematic review and meta-analysis, we searched PubMed, Embase, CINAHL and the WHO’s database of publications on novel coronavirus. We included English language studies that had described original demographic and clinical characteristics of children diagnosed with COVID-19 and reported on the presence or absence of gastrointestinal symptoms. Meta-analysis was conducted using the random-effects model. The pooled prevalence of gastrointestinal symptoms was expressed as proportion and 95% CI. Results The search identified 269 citations. Thirteen studies (nine case series and four case reports) comprising data for 284 patients were included. Overall, we rated four studies as having a low risk of bias, eight studies as moderate and one study as high risk of bias. In a meta-analysis of nine studies, comprising 280 patients, the pooled prevalence of all gastrointestinal symptoms was 22.8% (95% CI 13.1% to 35.2%; I2=54%). Diarrhoea was the most commonly reported gastrointestinal symptom followed by vomiting and abdominal pain. Conclusions Nearly a quarter of children with COVID-19 have gastrointestinal symptoms. It is important for clinicians to be aware of the gastrointestinal manifestation of COVID-19. PROSPERO registration number CRD42020177569.

中文翻译:

儿童 COVID-19 的胃肠道表现:系统评价和荟萃分析

目的 总结已发表的关于儿童 C​​OVID-19 胃肠道表现的证据,并确定胃肠道症状的患病率。方法 在这项系统评价和荟萃分析中,我们检索了 PubMed、Embase、CINAHL 和 WHO 的新型冠状病毒出版物数据库。我们纳入了描述被诊断为 COVID-19 的儿童的原始人口统计学和临床​​特征并报告了是否存在胃肠道症状的英语语言研究。使用随机效应模型进行荟萃分析。胃肠道症状的汇总患病率表示为比例和 95% CI。结果 搜索确定了 269 条引用。纳入了 13 项研究(9 个病例系列和 4 个病例报告),包含 284 名患者的数据。总体,我们将四项研究评为低偏倚风险,八项研究为中等偏倚风险,一项研究为高偏倚风险。在一项包含 280 名患者的九项研究的荟萃分析中,所有胃肠道症状的汇总患病率为 22.8%(95% CI 13.1% 至 35.2%;I2=54%)。腹泻是最常见的胃肠道症状,其次是呕吐和腹痛。结论 近四分之一的 COVID-19 患儿有胃肠道症状。临床医生了解 COVID-19 的胃肠道表现非常重要。PROSPERO 注册号 CRD42020177569。I2=54%)。腹泻是最常见的胃肠道症状,其次是呕吐和腹痛。结论 近四分之一的 COVID-19 患儿有胃肠道症状。临床医生了解 COVID-19 的胃肠道表现非常重要。PROSPERO 注册号 CRD42020177569。I2=54%)。腹泻是最常见的胃肠道症状,其次是呕吐和腹痛。结论 近四分之一的 COVID-19 患儿有胃肠道症状。临床医生了解 COVID-19 的胃肠道表现非常重要。PROSPERO 注册号 CRD42020177569。
更新日期:2021-06-07
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